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MLB Home Run Picks: Top Two Bets for Monday (Sept. 25)

Updated September 25, 2023 | 10:56 am CDT by Isaiah Sirois

The MLB rolls on, and despite the NFL doubleheader tonight, bettors can’t forget about the wild world of baseball. Tonight, I want action on a Padre to go yard, and OddsShopper’s model wants action on a Mariner. Let’s dive right into today’s best MLB home run picks and bets for Padres-Giants and Astros-Mariners. We’re trusting Manny Machado in Oracle Park this evening.

Few sweats are more fun than home run bets. If you want to start making money on your home run picks, positive expected value (+EV) each day. If you’re hungry for more than just the picks we post for free, sign up for OddsShopper today — new s can get their first month for 70% off.

Best MLB Home Run Bets & Picks Today for Monday, Sept. 25

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Padres-Giants Home Run Pick

When: 9:45 p.m. ET
Where: Oracle Park, San Francisco

Isaiah’s Target: Manny Machado at DraftKings

The San Diego Padres and San Francisco Giants are likely not headed to the playoffs this year, but, like the Fall Out Boy song, the Padres are going down swinging. They’re 9-1 through the last 10 games and have a distant shot at the final Wild Card spot, but they’ll need some help to get there. Still, the Padres are doing everything within their power to make a playoff push, and I expect big things from RHH Manny Machado tonight.

Machado takes on RHP Logan Webb, who has been pretty beatable this year — especially with regard to the long ball. Webb has coughed up 20 actual and 20.9 expected home runs this year. Only 16 would’ve gone over the fences at Oracle Park, but he’ll have to contend with 11.4 mph winds blowing out through left field tonight, which should help Machado and all other RHHs go yard. Webb is elite at home, but he has coughed up 12 home runs to RHHs this year, and they’re slashing .265/.298/.412 against him.

Machado has been instrumental to San Diego’s late-season surge, and, while he is better against LHPs than RHPs, he has been good against Webb. Machado has mashed 30 actual and 28 expected home runs this year, 23 of which have come against RHPs. He is slashing a respectable .238/.299/.449 against them, but, more importantly, he has a home run and is slashing .278/.300/.500 against Webb. With Machado slashing .294/.351/.676 with four home runs over the last 15 days, back him to go yard and record multiple bases tonight at DraftKings.

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Best MLB Home Run Bet: Manny Machado +700 at DraftKings

Astros-Mariners Home Run Pick

When: 9:40 p.m. ET
Where: T-Mobile Park, Seattle

OddsShopper’s Target: J.P. Crawford at FanDuel

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Crawford draws a matchup with RHP Justin Verlander. Although Verlander is always a tough opposing pitcher to face, he has coughed up seven home runs in September alone. Verlander has coughed up 18 actual and 17.3 expected home runs this year. Despite the tough matchup and unfriendly park, Crawford’s odds have just gotten too long. He has mashed 17 actual and 13.5 expected home runs this year, but 19 of his hits would’ve cleared the fences at T-Mobile Park.

The Our model thinks a fair price is +616 (13.9%), so we’re beating the market and getting some slight value by playing this MLB home run pick at +680 (12.8%) via FanDuel Sportsbook. This number may not remain on the market forever, so if you want to tail one of the model’s top home run picks today, get your action down soon!

Best MLB Home Run Bet: J.P. Crawford +680 at FanDuel

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Isaiah Sirois

Author

Isaiah Sirois

Isaiah Sirois is a sports betting analyst at OddsShopper specializing in basketball, football and motorsports. Basketball is Isaiah’s favorite sport to handicap, and he has covered NBA, WNBA, NCAA and FIBA markets for OddsShopper and other sites. However, Isaiah’s favorite sport to follow is auto racing, and you can usually find him watching NASCAR or IndyCar on Sundays. He will be a fan of Team Penske and Ford Performance until the end of time. Isaiah graduated with a bachelor’s degree in history from Emory University and briefly attended Vanderbilt Law School before dropping out to work at OddsShopper.

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